GUILT is no more. Dr. Derek Stiles and Nurse Angie Thompson faced humanity's greatest threat and triumphed. Now, in the aftermath, they find themselves in unknown territory, forced to deal with the disastrous consequences of the killer virus. Join them as they scramble to address questions left unanswered and put an end to the mystery behind the disease.
– True sequel to Under the Knife – Scrub back in to Nintendo DS for the next chapter of the award-winning Trauma Center: Under the Knife that returns to the tactile stylus-based experience that made the original a smash hit.
– Derek and Angie are back – Caduceus' preeminent surgical team returns to confront the aftermath of the devastating GUILT epidemic in a brand new story.
– Just what the doctor ordered – With a new easy-play mode, improved tool utility, and clearer directions, playing doctor has never been so much fun.
Trauma Center: Under the Knife 2 has been rated "T" for Teen with Blood, Mild Language, Mild Suggestive Themes, and Mild Violence by the ESRB.